SMPDL3A Antibody, FITC conjugated

Datasheet

Code	CSB-PA842119LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SMPDL3A Polyclonal antibody

Uniprot No.

Q92484

Target Names

SMPDL3A

Alternative Names

SMPDL3A antibody; ASML3AAcid sphingomyelinase-like phosphodiesterase 3a antibody; ASM-like phosphodiesterase 3a antibody; EC 3.1.4.- antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Acid sphingomyelinase-like phosphodiesterase 3a protein (51-350AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity.

Gene References into Functions

Activation of pregnane X receptor induces SMPDL3A expression in primary hepatocytes. PMID: 28414139
Site-specific N-glycosylation is essential for the intracellular stability, secretion and activity of human SMPDL3A. PMID: 28104755
Solved the structure of SMPDL3a revealing a calcineurin-like fold. A dimetal site, glycosylation pattern and a disulfide bond network are likely to be conserved also in aSMase. We show that the binuclear site of SMPDL3a is occupied by two Zn(2+) ions. PMID: 26783088
Data indicate that sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a nucleotide phosphodiesterase secreted from cholesterol-loaded macrophages. PMID: 25288789
the induction of SMPDL3A is liver X receptor-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. PMID: 22810003
ASML3a is involved in the process of bladder tumorigenesis PMID: 12442002

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Subcellular Location

Secreted.

Protein Families

Acid sphingomyelinase family

Tissue Specificity

Detected in blood serum. Detected in macrophages (at protein level).

Database Links

HGNC: 17389

OMIM: 610728

KEGG: hsa:10924

STRING: 9606.ENSP00000357425

UniGene: Hs.486357

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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